Mouse Monoclonal Antibody to MYST1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: MYST1 (MYST histone acetyltransferase 1, MOF) belongs to the MYST family of histone acetyltransferases, which are employed in the cell to bring about transcriptional regulation. The MYST family includes MYST1, is named for the founding members MOZ, yeast YBF2 and SAS2, and TIP60. All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein- protein interactions and targeting transcriptional regulators to chromatin. Although MOF is expressed in both males and females, it associates with the X chromosome only in males. MOF contains a zinc-finger domain that is used to contact the globular part of the nucleosome and histone H4. The carboxy terminal domain of human MOF also has histone acetyltransferase activity directed against histones H3 and H2A, a characteristic shared with other MYST family histone
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 8C4C4;
Isotype: Mouse IgG2b
Immunogen: Purified recombinant fragment of human MYST1 expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 53kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=153
Reference: 1. Sterner, D.E., et al. Microbiol. Mol. Biol 2000 Rev. 64: 435-459. ; 2. Neal, K.C., et al. Biochim. Biophys. 2000 Acta 1490: 170-174. ; 3. Akhtar, A., et al. EMBO 2001 Rep. 2: 113-118. ;

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