Mouse Monoclonal Antibody to AGT

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 1B1;
Isotype: Mouse IgG2b
Immunogen: Purified recombinant fragment of human AGT expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 53kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=340
Reference: 1. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1900-7. ; 2. Regul Pept. 2006 Jan 15;133(1-3):155-9.

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