Mouse Monoclonal Antibody to AFP

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: AFP (alpha-fetoprotein), a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 6E6;
Isotype: Mouse IgG2b
Immunogen: Purified recombinant fragment of human AFP expressed in E. Coli.
Formulation: Antibody are purified by protein G affinity chromatography. ; Liquid in PBS containing 50% glycerol and 0.03% sodium azide. ;
MW: 69kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=371
Reference: 1. Proc Natl Acad Sci U S A. 1985 Nov;82(21):7160-4. ; 2. Pediatr Hematol Oncol. 2001 Dec;18(8):509-18. ; 3. Tumour Biol. 2002 Jul-Aug;23(4):202-11.

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