Mouse Monoclonal Antibody to ROCK1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. 
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 1H4;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human ROCK1 expressed in E. Coli. ;
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 158kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=703
Reference: 1. Am J Physiol Heart Circ Physiol. 2009 Mar;296(3):H893-9. ; 2. Cancer Metastasis Rev. 2009 Jun;28(1-2):65-76.  ;

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