Mouse Monoclonal Antibody to SKP1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 1H9;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human SKP1 expressed in E. Coli. ;
Formulation: Ascitic fluid containing 0.03% sodium azide. ;
MW: 19kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=715
Reference: 1.J Biol Chem. 2008 Nov 7;283(45):30796-803. ; 2.Cell. 2009 Jul 23;138(2):389-403. ;

Note: Highly recommend to send quote request for product availability and estimated shipping charge