Mouse Monoclonal Antibody to WHSC2

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. ; ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Rat
Clone: 6B11H8;
Isotype: Mouse IgG2b
Immunogen: Purified recombinant fragment of human WHSC2 (AA: 280-511) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 57.3kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=913
Reference: 1.Hum Mol Genet. 2012 May 15;21(10):2181-93. ; 2.Exp Cell Res. 2009 Jun 10;315(10):1693-705. ;

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