Mouse Monoclonal Antibody to ERCC1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009];
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: ; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 1E5B3;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human ERCC1 (AA: 151-297) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 32.6kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=3743
Reference: Lung Cancer. 2013 Nov;82(2):324-9. ; Cancer. 2013 Sep 1;119(17):3242-50.;

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