Mouse Monoclonal Antibody to CFHR5

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 3E1E10;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human CFHR5 (AA: 344-569) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 64.4kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4115
Reference: 1.Kidney Int. 2014 Apr;85(4):933-7. ; 2.Dis Model Mech. 2011 Nov;4(6):721-6.;

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