Mouse Monoclonal Antibody to RAD50

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: ; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Rat
Clone: 3D2G10;
Isotype: Mouse IgG2a
Immunogen: Purified recombinant fragment of human RAD50 (AA: 228-359) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 154kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4126
Reference: 1.Breast Cancer Res Treat. 2010 Sep;123(2):607-9. ; 2.Dis Markers. 2008;24(2):127-34.;

Note: Highly recommend to send quote reqeust for estimated shipping charge including ice