Mouse Monoclonal Antibody to TRAF2

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 5C2C3;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human TRAF2 (AA: 39-188) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 55.8KD
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4155
Reference: 1.J Virol. 2014 Apr;88(7):3664-77. ; 2.Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Nov;27(11):1176-9.;

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