Mouse Monoclonal Antibody to PYCARD

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 1C3D7;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human PYCARD (AA: 1-120) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 21.6kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4159
Reference: 1.J Invest Dermatol. 2013 Feb;133(2):518-27. ; 2.Cancer Sci. 2010 Aug;101(8):1822-7.;

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