STAT6 Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Signal transduction
Applications: WB,ELISA
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Concentration: 0.2mg/mL
Swissprot: P42226
Gene Accession: BC075852
Reactivity: Human,Mouse
Host: Rabbit
Isotype: IgG
Immunogen: Recombinant protein of human STAT6
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 94kDa
Tissue Specificity/Positive Control:
Cellular Localization: Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-stat6_polyclonal_antibody-30118.html
Manual Link: https://www.elabscience.com/viewpdf-30118-elabscience-E-AB-10059.PDF