cPLA2 Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Research Areas: Cancer, Cardiovascular, Metabolism, Immunology, Signal transduction
Applications: WB,IHC,ELISA
Recommended Dilutions: WB 1:500-1:2000, IHC 1:50-1:200
Size: 200 uL
Concentration: 0.4mg/mL
Swissprot: P47712
Gene Accession: BC114340
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Recombinant protein of human PLA2G4A
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 85kDa
Tissue Specificity/Positive Control: Expressed in various tissues such as macrophages, platelets, neutrophils, fibroblasts and lung endothelium.
Cellular Localization: Cytosol,Endoplasmic reticulum,endoplasmic reticulum membrane,Golgi apparatus,Golgi apparatus,Mitochondrion,mitochondrial inner membrane,Other locations:cytoplasmic vesicle,lipid droplet
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-cpla2_polyclonal_antibody-31140.html
Manual Link: https://www.elabscience.com/viewpdf-31140-elabscience-E-AB-11099.PDF