14-3-3 sigma Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
Research Areas: Cancer, Neuroscience, Signal transduction, Stem cells
Applications: WB
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Concentration: 1.69mg/mL
Swissprot: P31947
Gene Accession:
Reactivity: Human
,Mouse

Host: Rabbit
Isotype: IgG
Immunogen: Recombinant protein of human SFN
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 28kDa
Tissue Specificity/Positive Control: Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Cellular Localization: Cytoplasm. Nucleus. Secreted. May be secreted by a non-classical secretory pathway.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-14_3_3_sigma_polyclonal_antibody-39721.html
Manual Link: https://www.elabscience.com/viewpdf-39721-elabscience-E-AB-11702.PDF