CREBZF Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: Host cell factor (HCF) is a cellular cofactor required for the activation of VP16 which expresses the herpes simplex virus immediate early gene. V16 binds to HCF through a 4-amino acid motif similar to the HCF binding domain of the basic leucine-zipper proteins Luman and Zhangfei (ZF). Luman activates promoters containing cAMP or unfolded protein response elements (UPRE). Zhangfei suppresses the transcriptional activity of Luman, but requires HCF binding which may target Luman and Zhangfei to a common location. Sequence analysis predicts that the deduced 272-amino acid Zhangfei protein has a negatively charged N terminus, a leucine zipper of 6 heptad leucine repeats separated by a conserved 6-amino acid spacer, a basic domain, and a bZIP region. It is also presumed that the N-terminal acidic region of Zhangfei is an activation domain.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Applications: WB,IHC,ELISA
Recommended Dilutions: WB 1:500-1:2000, IHC 1:25-100
Size: 200 uL
Concentration: 2mg/mL
Swissprot: Q9NS37
Gene Accession: NP_001034707
Reactivity: Human
,Mouse

Host: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of human CREBZF
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 37kDa
Tissue Specificity/Positive Control: In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low amounts in heart, lung and liver.
Cellular Localization: Nucleus. Colocalizes at punctate nuclear structures with CREB3 and HCFC1.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-crebzf_polyclonal_antibody-40039.html
Manual Link: https://www.elabscience.com/viewpdf-40039-elabscience-E-AB-12199.PDF