PDE4D Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
Research Areas: Cancer, Signal transduction
Applications: WB,IHC,ELISA
Recommended Dilutions: WB 1:500-1:2000, IHC 1:25-1:100
Size: 200 uL
Concentration: 0.2mg/mL
Swissprot: Q08499
Gene Accession: NP_001098101
Reactivity: Human
Host: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of human PDE4D
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 91kDa
Tissue Specificity/Positive Control: Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
Cellular Localization: Cytoplasm. Membrane. Cytoplasm>cytoskeleton. Cytoplasm>cytoskeleton>centrosome. Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-pde4d_polyclonal_antibody-36090.html
Manual Link: https://www.elabscience.com/viewpdf-36090-elabscience-E-AB-16695.PDF