VPS4B Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16.
Research Areas: Signal transduction
Applications: IHC,ELISA
Recommended Dilutions: IHC 1:10-50, ELISA 1:1000-2000
Size: 200 uL
Concentration: 0.9mg/mL
Swissprot: O75351
Gene Accession: NP_004860
Reactivity: Human
Host: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of human VPS4B
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW:
Tissue Specificity/Positive Control: Ubiquitously expressed.
Cellular Localization: Prevacuolar compartment membrane. Late endosome membrane. Membrane-associated in the prevacuolar endosomal compartment. Localized in HIV-1 particles purified from acutely infected cells.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-vps4b_polyclonal_antibody-36952.html
Manual Link: https://www.elabscience.com/viewpdf-36952-elabscience-E-AB-17557.PDF