Phospho-cPLA2 (Ser505) Polyclonal Antibody

Supplier: Elabscience
Product Category: Phospho/Acetyl/Methyl
Description: This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Research Areas: Cancer, Cardiovascular, Metabolism, Immunology, Signal transduction
Size: 200 uL
Concentration: 1mg/mL
Applications: WB,IHC-p,IF,ELISA
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:10000
Clonality: Polyclonal
Clone No:
SwissProt: P47712
Gene ID: 5321
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from human cPLA2 around the phosphorylation site of Ser505
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Conjugation: Unconjugated
Observed MW: 110kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cytosol,Endoplasmic reticulum,endoplasmic reticulum membrane,Golgi apparatus,Golgi apparatus,Mitochondrion,mitochondrial inner membrane,Other locations:cytoplasmic vesicle,lipid droplet

Product Link: https://www.elabscience.com/p-phospho_cpla2_(ser505)_polyclonal_antibody-41110.html
Manaul Link: https://www.elabscience.com/viewpdf-41110-elabscience-E-AB-21469.PDF