ABCC2 Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
Research Areas: Cancer, Metabolism, Signal transduction
Applications: IHC,ELISA
Recommended Dilutions: IHC 1:30-150, ELISA 1:2000-10000
Size: 200 uL
Concentration: 0.6mg/mL
Swissprot: Q92887
Gene Accession: NP_000383
Reactivity: Human
Host: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of human ABCC2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW:
Tissue Specificity/Positive Control: Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.
Cellular Localization: Membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-abcc2_polyclonal_antibody-36747.html
Manual Link: https://www.elabscience.com/viewpdf-36747-elabscience-E-AB-17352.PDF