AATF Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Research Areas: Cell Biology, Epigenetics and Nuclear Signaling
Applications: WB,IHC-p,ELISA
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Size: 200 uL
Concentration: 1mg/mL
Swissprot: Q9NY61
Gene Accession:
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from the N-terminal region of human Che-1
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 63kDa
Tissue Specificity/Positive Control: Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.
Cellular Localization: Nucleus>nucleolus.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-aatf_polyclonal_antibody-27232.html
Manual Link: https://www.elabscience.com/viewpdf-27232-elabscience-E-AB-30907.PDF