Phospho-TERF1 (Ser219) Polyclonal Antibody

Supplier: Elabscience
Product Category: Phospho/Acetyl/Methyl
Description: Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Tags & Cell Markers
Size: 200 uL
Concentration: 1mg/mL
Applications: WB,ELISA
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:5000
Clonality: Polyclonal
Clone No:
SwissProt: P54274
Gene ID: 7013
Reactivity: Human,Mouse
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from human TRF1 around the phosphorylation site of S219.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Conjugation: Unconjugated
Observed MW: 55kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Nucleus. Cytoplasm>cytoskeleton>spindle. Chromosome>telomere. Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Associates with the mitotic spindle.

Product Link: https://www.elabscience.com/p-phospho_terf1_(ser219)_polyclonal_antibody-25647.html
Manaul Link: https://www.elabscience.com/viewpdf-25647-elabscience-E-AB-21058.PDF