Phospho-TEK (Tyr992) Polyclonal Antibody

Supplier: Elabscience
Product Category: Phospho/Acetyl/Methyl
Description: The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smootHuman, Mouseuscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
Research Areas: Cancer, Cardiovascular, Developmental biology, Signal transduction, Stem cells
Size: 200 uL
Concentration: 1mg/mL
Applications: WB,ELISA
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:10000
Clonality: Polyclonal
Clone No:
SwissProt: Q02763
Gene ID: 7010
Reactivity: Human,Mouse
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from human Tie-2 around the phosphorylation site of Tyr992
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Conjugation: Unconjugated
Observed MW: 125kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cell membrane. Cell junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Secreted. Recruited to cell-cell contacts in quiescent endothelial cells. Colocalizes with the actin cytoskeleton and at actin stress fibers during cell spreading. Recruited to the lower surface of migrating cells, especially the rear end of the cell. Proteolytic processing gives rise to a soluble extracellular domain that is secreted.

Product Link: https://www.elabscience.com/p-phospho_tek_(tyr992)_polyclonal_antibody-25657.html
Manaul Link: https://www.elabscience.com/viewpdf-25657-elabscience-E-AB-21068.PDF