Phospho-SH-PTP1 (Tyr536) Polyclonal Antibody

Supplier: Elabscience
Product Category: Phospho/Acetyl/Methyl
Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
Research Areas: Cancer, Cell Biology, Developmental biology, Signal transduction
Size: 200 uL
Concentration: 1mg/mL
Applications: WB,IHC-p,ELISA
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Clonality: Polyclonal
Clone No:
SwissProt: P29350
Gene ID: 5777
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from human SH-PTP1 around the phosphorylation site of Y536.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Conjugation: Unconjugated
Observed MW: 67kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.

Product Link: https://www.elabscience.com/p-phospho_sh_ptp1_(tyr536)_polyclonal_antibody-25714.html
Manaul Link: https://www.elabscience.com/viewpdf-25714-elabscience-E-AB-21125.PDF