Phospho-TNS1 (Tyr1326) Polyclonal Antibody

Supplier: Elabscience
Product Category: Phospho/Acetyl/Methyl
Description: The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms.TNS1 (Tensin 1) is a Protein Coding gene. Diseases associated with TNS1 include Bannayan-Riley-Ruvalcaba Syndrome and Ruvalcaba Syndrome. Among its related pathways are Focal Adhesion and Integrin Pathway. GO annotations related to this gene include poly(A) RNA binding and actin binding. An important paralog of this gene is TNS3.
Research Areas: Signal transduction
Size: 200 uL
Concentration: 1mg/mL
Applications: WB,ELISA
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:20000
Clonality: Polyclonal
Clone No:
SwissProt: Q9HBL0
Gene ID: 7145
Reactivity: Human,Mouse
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from human Tensin-1 around the phosphorylation site of Tyr1326
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Conjugation: Unconjugated
Observed MW: 185kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cell surface. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.

Product Link: https://www.elabscience.com/p-phospho_tns1_(tyr1326)_polyclonal_antibody-25893.html
Manaul Link: https://www.elabscience.com/viewpdf-25893-elabscience-E-AB-21304.PDF