Phospho-SGK1 (Ser78) Polyclonal Antibody

Supplier: Elabscience
Product Category: Phospho/Acetyl/Methyl
Description: Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.
Research Areas: Cancer, Developmental biology, Signal transduction, Stem cells
Size: 200 uL
Concentration: 1mg/mL
Applications: WB,ELISA
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:10000
Clonality: Polyclonal
Clone No:
SwissProt: O00141
Gene ID: 6446
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from human SGK1 around the phosphorylation site of Ser78
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Conjugation: Unconjugated
Observed MW: 54kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cell membrane and Cytoplasm. Nucleus. Endoplasmic reticulum. Nuclear, upon phosphorylation.

Product Link: https://www.elabscience.com/p-phospho_sgk1_(ser78)_polyclonal_antibody-41125.html
Manaul Link: https://www.elabscience.com/viewpdf-41125-elabscience-E-AB-21387.PDF