Mouse Monoclonal Antibody to ApoB

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene product is the main apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 6G6;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human ApoB expressed in E. Coli. ;
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 516kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=613
Reference: 1. Cell Host Microbe. 2008 Dec 11;4(6):555-66. ; 2. Atherosclerosis. 2009 Sep;206(1):17-30.

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