Mouse Monoclonal Antibody to ABCB1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 6G11F8;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human ABCB1 (AA: 632-693) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 141.5kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=3554
Reference: 1. Pharmacol Rep. 2012;64(6):1560-6. ; 2. J Cancer Res Ther. 2012 Apr-Jun;8(2):226-31. ;

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