Mouse Monoclonal Antibody to GLP20060
Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from enteroendocrine L cells in response to ingested nutrients. The closely related peptides glucagon-like peptide (GLP-1) and glucagon have opposing effects on blood glucose. GLP-1 induces glucose-dependent insulin secretion in the pancreas, while glucagon stimulates gluconeogenesis and glycogenolysis in the liver. Glucagon is processed from a large precursor, proglucagon, in a tissue-specific manner in pancreatic alpha-cells. The identification of a hybrid peptide acting as both a GLP-1 agonist and a glucagon antagonist would provide a novel approach for the treatment of type 2 diabetes.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of GLP expressed in E. Coli.
Formulation: Purified antibody in PBS containing 0.03% sodium azide.
Storage: 4C; -20C for long term storage
Spplier link: http://www.promab.com/index.php?main_page=product_info&products_id=85
Reference: 1. Clark Q. Pan, Joanne M. Buxton, Stephanie L. Yung, et al. J Biol Chem. 2006 Feb 27. ; 2.Michael F. Crutchlow, Jee-Young Nina Ham, et al. Int J Biochem Cell Biol. 2006;38(5-6):845-859. ; 3.Andrew Young Adv Pharmacol. 2005;52:151-71. ;