Mouse Monoclonal Antibody to MER

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: MER (c-mer proto-oncogene tyrosine kinase) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MER has been identified as a tyrosine kinase potentially involved in the development of glioblastomas. It is expressed at highest levels in ovary, prostate, lung and kidney. Gas6, a growth arrest specific gene, and the related anticoagulation factor Protein S have been identified as ligands for the UFO family of receptors. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 7E5G1;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of MER expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: N/A
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=166
Reference: 1. McGough N. Cummings JH. Proc Nutr Soc.2005, Nov,64(4):434-50. Review. ; 2. Allouache D. Gawande SR. Tubiana-Hulin M. et al. BMC Cancer. 2005, Nov 29,5:151. ; 3. Seguineau C. Soudant P. Moal J. et al. Lipids.2005, Sep,40(9): 931-9. ;

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