Mouse Monoclonal Antibody to PARL20241
Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: PARL: presenilin associated, rhomboid-like. This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Isotype: Mouse IgG2b
Immunogen: Purified recombinant fragment of PARL (aa112-167) expressed in E. Coli. ;
Formulation: Ascitic fluid containing 0.03% sodium azide. ;
Storage: 4C; -20C for long term storage
Spplier link: http://www.promab.com/index.php?main_page=product_info&products_id=237
Reference: 1. J Alzheimers Dis. 2001 Apr;3(2):181-190. ; 2. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. ; 3. Nature. 2003 May 29;423(6939):537-41.