Mouse Monoclonal Antibody to Oct4

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Oct4: octamer-binding transcription factor-4 (Oct-4, Otf-4) and Oct-3/4, also known as POU5F1(POU class 5 homeobox 1), octamerbinding transcription factor-3 (Oct-3, Otf-3), modulates embryonic stem (ES) cell populations by influencing lineage commitment. Entrez Protein NP_002692. Oct-3/4 sustains stem-cell selfrenewal and differentiation pathways. Transcription factors containing the POU homeodomain regulate tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development. Oct-3/4 is capable of inducing rapid proliferation and tumorigenic properties of ES cells through activation of the UTF1 gene. In humans, two Oct-3/4 isoforms contribute to influencing the undifferentiated phenotype of ES cells. Oct-3/4 pseudogenes localizing to human chromosomes 10 and 8 are reported to be transcribed in certain cancer cell lines and tissues.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 1D10H6;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of Oct4 (aa193-360) expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide. ;
MW: 38.5kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=280
Reference: 1. Cells Tissues Organs. 2006;184(3-4):105-16. ; 2. Int J Cancer. 2007 Apr 1;120(7):1598-602. ;

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