Mouse Monoclonal Antibody to TrkA

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: TrkA, also known as NTRK1, MTC, TRK, TRK1. It is a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 6B2;
Isotype: Mouse IgG1
Immunogen: Purified recombinant extracellular fragment of human TrkA (aa33-423) fused with hIgGFc tag expressed in HEK293 cell line.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 87.4kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=318
Reference: 1. DNA Repair (Amst). 2008 Oct 1;7(10):1757-64. ; 2. Traffic. 2008 Jul;9(7):1146-56.

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