Mouse Monoclonal Antibody to PTEN

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: PTEN (phosphatase and tensin homolog) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. This protein is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Mouse;
Clone: 1B8;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of PTEN expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 54kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=369
Reference: 1. Nat Genet. 1998 Aug;19(4):348-55.; 2. Oncogene. 1999 May 20;18(20):3181-5.; 3. Eur J Immunol. 2002 Apr;32(4):1196-204.;

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