Mouse Monoclonal Antibody to ZBTB7B

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: ZBTB7B is a transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is a transcriptional repressor of the collagen COL1A1 and COL1A2 genes. It may also function as a repressor of fibronectin and possibly other extracellular matrix genes.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 7C12;
Isotype: Mouse lgG1
Immunogen: Purified recombinant fragment of human ZBTB7B expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 58kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=411
Reference: 1.Proc Natl Acad Sci U S A. 1994 Sep 27;91(20):9372-6. ; 2.J Biol Chem. 2000 Sep 1;275(35):27421-38. ; 3.J Cell Biochem. 2009 Aug 15;107(6):1037-45. Review.

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