Mouse Monoclonal Antibody to SYP

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Synaptophysin (p38) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells.Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore. Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases. Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Hunam; Rat
Clone: 7H12;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of SYP expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 33.8kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=432
Reference: 1. Cancer. 2007 Oct 15;110(8):1776-81. ; 2. J Gastroenterol Hepatol. 2008 Oct;23(10):1574-85. ; 3. Virchows Arch. 2009 Aug;455(2):125-32.

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