Mouse Monoclonal Antibody to SMAD630097
Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions.Tissue specificity: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human SMAD6 expressed in E. Coli. ; ;
Formulation: Ascitic fluid containing 0.03% sodium azide.
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=496
Reference: 1. J Biol Chem. 2006 Feb 10;281(6):3569-76. ; 2. Nat Immunol. 2006 Oct;7(10):1057-65. ; 3. J Med Genet. 2009 May;46(5):331-7.
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