Mouse Monoclonal Antibody to CDH1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. In addition to being a calcium-dependent adhesion molecule, E-Cadherin is also a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. Tyrosine phosphorylation can disrupt these complexes, leading to changes in cell adhesion properties. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.Tissue specificity: Non-neural epithelial tissues.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Mouse; Monkey
Clone: 7A2;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human CDH1 expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide. ;
MW: 135kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=526
Reference: 1. Nat Genet. 2009 Dec;41(12):1330-4. ; 2. Zhonghua Zhong Liu Za Zhi. 2009 Jul;31(7):515-9. ; 3. J Biol Chem. 2010 Feb 26;285(9):6658-69.

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