Mouse Monoclonal Antibody to PSIP1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration. Tissue specificity: Widely expressed. Expressed at high level in the thymus. Expressed in fetal and adult brain. Expressed in neurons, but not astrocytes. Markedly elevated in fetal as compared to adult brain. In the adult brain, expressed in the subventricular zone (SVZ), in hippocampus, and undetectable elsewhere. In the fetal brain, expressed in the germinal neuroepithelium and cortical plate regions.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Monkey; Rat
Clone: 6E4;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human PSIP1 expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 75kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=551
Reference: 1. J Virol. 2008 Dec;82(23):11555-67. ; 2. Proteins. 2008 Aug;72(2):635-45.

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