Mouse Monoclonal Antibody to OLIG2

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. Tissue specificity: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 1G11;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human OLIG2 expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 32kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=566
Reference: 1. Am J Med Genet B Neuropsychiatr Genet. 2008 Jun 5;147B(4):538-9. ; 2. Virchows Arch. 2007 May;450(5):575-84.

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