Mouse Monoclonal Antibody to GCK

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 4G6;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human GCK expressed in E. Coli. ;
Formulation: Ascitic fluid containing 0.03% sodium azide.
MW: 52kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=642
Reference: 1. Mol Endocrinol. 2009 Dec;23(12):1983-9. ; 2. Int J Mol Med. 2009 Aug;24(2):233-46.

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