Mouse Monoclonal Antibody to MMP2

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. ; ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 4D1E2;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human MMP2 (AA: 242-396) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 73.8kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=839
Reference: 1.Br J Cancer. 2012 Apr 24;106(9):1495-8. ; 2.Iran J Immunol. 2011 Jun;8(2):120-6. ;

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