Mouse Monoclonal Antibody to PSAP

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. ; ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/50-1/500; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 4D5F4;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human PSAP (AA: 325-524 ) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 58.1kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=843
Reference: 1.Biochem J. 2012 Jan 15;441(2):665-74. ; 2.Mol Cancer. 2010 Feb 4;9:30. ;

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