Mouse Monoclonal Antibody to CD22

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: CD22 may be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 2H1C4;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human CD22 (AA: 621-725) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 95.3kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=3511
Reference: 1. Cancer Res. 2012 Nov 1;72(21):5556-65. ; 2. J Innate Immun. 2011;3(4):411-9. ;

Note: Highly recommend to send quote request for product availability and estimated shipping charge