Mouse Monoclonal Antibody to CD10

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. ; ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 5E9A5;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human CD10 (AA: 52-246) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 85.5kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=3539
Reference: 1. Pathol Res Pract. 2012 May 15;208(5):281-5. ; 2. J Dermatol Sci. 2013 Feb;69(2):105-13. ;

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