Mouse Monoclonal Antibody to PRKACA

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 7H3A4;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human PRKACA (AA: 1-120) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide.
MW: 40.6kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=3637
Reference: 1. J Struct Biol. 2012 Jun;178(3):300-10.; 2. BMC Biochem. 2011 Aug 3;12:40.

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