Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Isotype: Mouse IgG2b
Immunogen: Purified recombinant fragment of human RAP1GAP (AA: 412-678) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide.
Storage: 4C; -20C for long term storage
Spplier link: http://www.promab.com/index.php?main_page=product_info&products_id=3665
Reference: 1. Endocr Relat Cancer. 2012 Jul 22;19(4):575-88.; 2. Cancer Lett. 2012 Jul 1;320(1):65-71.