Mouse Monoclonal Antibody to PLCG1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. ;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human; Monkey; Rat
Clone: 3C2D11;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human PLCG1 (AA: 1192-1291) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 148.5kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4010
Reference: 1.Cancer Discov. 2014 Apr;4(4):OF13. ; 2.Int J Cancer. 2013 Mar 1;132(5):1022-31.;

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