Mouse Monoclonal Antibody to MECP2

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 8H4A5B9;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human MECP2 (AA: 7-148) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 52.4kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4054
Reference: 1.J Pediatr Surg. 2013 Oct;48(10):2099-105. ; 2.Cell Res. 2013 Nov;23(11):1244-6.;

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