Mouse Monoclonal Antibody to ACVR1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.;
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: ; ICC: ; FCM: 1/200 - 1/400
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 2C1E8;
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human ACVR1 (AA: 21-120) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 72kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4294
Reference: 1.Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15438-43. ; 2.Br J Cancer. 2012 Dec 4;107(12):1978-86. ;

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