Mouse Monoclonal Antibody to GRM1

Supplier: ProMab Technologies
Type of Product: Monoclonal Antibody
Description: This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: N/A; FCM: N/A; IHC: N/A
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 5E12D8
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human GRM1 (AA: extra 387-486) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 132.4kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4434
Reference: 1.Breast Cancer Res Treat. 2015 May;151(1):57-73.2.PLoS One. 2013 Jul 26;8(7):e69851.

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